Motif

Overview

This page provides comprehensive information about transcription factor binding motifs, including their sequence characteristics, binding preferences, associated variants, and regulatory effects. Motifs represent DNA sequence patterns recognized by transcription factors.

Motif Properties

This table displays detailed properties of this transcription factor binding motif.

Column	Description
Motif ID	Unique identifier for the motif
Motif Family	Family classification of the motif
Consensus Sequence	Consensus DNA sequence
Information Content	Information content score
Binding Affinity	Relative binding affinity
Strand Specificity	Whether binding is strand-specific
Evolutionary Conservation	Conservation level across species
Source Database	Source database or collection

This table provides details about the transcription factor binding motif.

Column	Description
Name	Name of the binding motif (click for motif details)
TF Name	Name of the transcription factor
Length	Length of the motif in base pairs
PWM	Position Weight Matrix for the motif
Source	Source of the motif data (click for more details)

Associated Proteins

This table shows proteins associated with this transcription factor binding motif.

Column	Description
Protein	Protein identifier (click for protein details)
Full Name	Complete name of the protein
Protein Source	Source of the protein information
Source URL	URL to the source database (click for external link)
Database References	Cross-references to other databases
Motif Source	Source of the motif association

Variant Effects on Binding

This table shows genetic variants that affect transcription factor binding to this motif.

Column	Description
Variant (rsID)	Genetic variant affecting binding
Position in Motif	Position within the motif sequence
Reference Allele	Reference nucleotide
Alternate Allele	Alternate nucleotide
Binding Score Change	Change in binding affinity
Fold Change	Fold change in binding strength
P-value	Statistical significance of binding change
Functional Impact	Predicted functional consequence
Source	Source of binding effect data

Regulatory Targets

This table shows genes regulated by transcription factors that bind to this motif.

Column	Description
Target Gene	Gene regulated by the transcription factor
Regulatory Element	Type of regulatory element (enhancer, promoter, etc.)
Distance to TSS	Distance from transcription start site
Cell Type	Cell type where regulation occurs
Effect Direction	Direction of regulatory effect (activation/repression)
Evidence Type	Type of regulatory evidence
Source	Source of regulatory data

Disease Associations

This table displays diseases associated with disruption of transcription factor binding to this motif.

Column	Description
Disease	Associated disease or condition
Variant	Causal variant affecting binding
Affected Gene	Gene with altered regulation
Mechanism	Molecular mechanism of disease
Evidence Level	Strength of disease association
PMID	Supporting publications
Source	Source of disease association

Each table can be sorted by clicking on the column headers. You can also use the search box above each table to filter the results.

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Motif

Overview

Motif Properties

Motif

Associated Proteins

Variant Effects on Binding

Regulatory Targets

Disease Associations

​Overview

​Motif Properties

​Motif

​Associated Proteins

​Variant Effects on Binding

​Regulatory Targets

​Disease Associations

Overview

Motif Properties

Motif

Associated Proteins

Variant Effects on Binding

Regulatory Targets

Disease Associations