This documentation targets the production Catalog API. Base URL: https://api.catalogkg.igvf.org/api.

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IGVF Catalog REST API

The IGVF Catalog exposes an OpenAPI-compliant REST API for querying the genomics knowledge graph: variants, genes, proteins, regulatory elements, QTLs, pathways, drugs, and more.

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Base URL

Interactive Swagger UI: api.catalogkg.igvf.org

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Pagination

  • page — 0-based page index (default 0)
  • limit — page size; maximum 500 on most endpoints
Example: GET /variants?region=chr1:1157520-1158189&page=0

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Coordinates

The database uses 0-based, half-open genomic coordinates on GRCh38 (human) and GRCm39 (mouse).

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Query patterns

Most endpoints accept one primary filter plus optional refinements. Examples in each endpoint description are tested individually (see audit results).

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Variant identifiers

Variants can be queried by any of:

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Dataset provenance (files_fileset)

Many edges are tagged with a files_fileset accession (e.g. IGVFFI9602ILPC, ENCFF968BZL) linking Catalog results to source files on the IGVF Portal or ENCODE Portal. See Data Sources and Field lineage for file metadata and column-to-API field mappings.